Obesity Linked To Early Diabetes
The researchers concluded that obesity is associated with the onset of diabetes, a breakthrough that they say could lead to the development of drugs for the prevention of the disease.
A new study has shown that fat cells release proteins called factors pigment epithelium origin, the muscles and liver to ignore the insulin, causing a series of events and interactions, the development of diabetes type 2.
Professor Matthew W. Monash University, who led the group, said: “When PEDF in the blood, it causes the muscles and liver to insulin for desensitized. Pancreas to produce more insulin, then these negative effects.
“This leads to the release of insulin in the pancreas overweight, perhaps to slow or stop the release of insulin from the pancreas, which leads to type 2 diabetes.
“It seems that the more fat a person less sensitive to insulin. Thus, no need for insulin, the body to regulate blood glucose.
“Our research has shown that increased PEDF not only the causes of type 2 diabetes, such as complications, but it does not cancel the effects of PEDF. The body will be returned to the insulin-sensitive, and therefore do not need more insulin to be regulated. ”
According to researchers, the identification of the links is a significant breakthrough in the declaration of the causes of obesity triggers the beginning of type 2 diabetes.
“Until now, scientists knew that it was very clear and very strong suspicion that there is a relationship between these two conditions, but our understanding of the chain of events caused by the release of PEDF has shown a causal link .
Diabetes type-2 patients know that these two conditions are linked. We already know that weight loss generally improves regulation of blood sugar in diabetics.
“Scientists are now waiting to know the link exists, and we can start adding new drugs to improve treatment of type 2 diabetes,” said Professor Watts.
The results, published in the latest edition of “Cell Metabolism” were published.